R&D Associate Director & Fellow – Neuromodulation at Boston Scientific

Dr Rosana Esteller received her B.Sc. in EE and M.Sc. in BE from Simon Bolivar University, and her Ph.D. degree in Electrical Engineering from Georgia Institute of Technology. She was principal and founder of IntelliMedix Inc., which later merged with NeuroPace Inc., where her contributions were pivotal for the RNSTM seizure detection built-in algorithms and where she led critical clinical studies that led to the pre- market approval of the first closed loop implantable neuromodulation device. Since 2016, she has worked with Boston Scientific, where she is now Associate Director and Scientific Fellow in the Neuromodulation Research and Advanced Concepts (NRAC) group. In NRAC, she leads and manages research scientists with the primary goal of designing novel and future neuromodulation technologies to treat neurological disorders such as Parkinson’s, chronic pain, and others. She has 25+ years of industry experience in neuromodulation, mostly in closed loop medical devices, algorithm development, and clinical studies, areas where her leadership experience has motivated expert teams to achieve at the highest levels. She has over 50 journal and conference publications, three chapter-books, and over 40+ patents.

Select Publications

Epileptic seizures may begin hours in advance of clinical onset: a report of five patients

B Litt, R Esteller, J Echauz, M D’Alessandro, R Shor, T Henry, P Pennell, …
Neuron 30 (1), 51-64
733 2001
A comparison of waveform fractal dimension algorithms

R Esteller, G Vachtsevanos, J Echauz, B Litt
IEEE Transactions on Circuits and Systems I: Fundamental Theory and …
527 2001
Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control

R Esteller, JR Echauz, B Litt, GJ Vachtsevanos
US Patent 6,594,524
479 2003
Epileptic seizure prediction using hybrid feature selection over multiple intracranial EEG electrode contacts: a report of four patients

M D’Alessandro, R Esteller, G Vachtsevanos, A Hinson, J Echauz, B Litt
IEEE transactions on biomedical engineering 50 (5), 603-615
344 2003
Line length: an efficient feature for seizure onset detection

R Esteller, J Echauz, T Tcheng, B Litt, B Pless
2001 Conference Proceedings of the 23rd Annual International Conference of …
299 2001
Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity

B Litt, G Vachtsevanos, J Echauz, R Esteller
US Patent 6,658,287
260 2003
Patient-specific parameter selection for neurological event detection

J Echauz, R Esteller, TK Tcheng, BD Pless
US Patent 7,177,674
237 2007
Patient-specific template development for neurological event detection

BD Pless, TK Tcheng, E Kishawi, B Gibb, J Echauz, R Esteller
US Patent 7,136,695
222 2006
Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device

JR Echauz, R Esteller, B Litt, GJ Vachtsevanos
US Patent 7,333,851
194 2008
Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device

JR Echauz, R Esteller, B Litt, GJ Vachtsevanos
US Patent 6,678,548
142* 2004
Continuous energy variation during the seizure cycle: towards an on-line accumulated energy

R Esteller, J Echauz, M D’Alessandro, G Worrell, S Cranstoun, …
Clinical neurophysiology 116 (3), 517-526
129 2005
A multi-feature and multi-channel univariate selection process for seizure prediction

M D’Alessandro, G Vachtsevanos, R Esteller, J Echauz, S Cranstoun, …
Clinical neurophysiology 116 (3), 506-516
120 2005
Detection of seizure precursors from depth-EEG using a sign periodogram transform

JJ Niederhauser, R Esteller, J Echauz, G Vachtsevanos, B Litt
IEEE Transactions on Biomedical Engineering 50 (4), 449-458
112 2003
Sensitivity of quantitative EEG for seizure identification in the intensive care unit

HA Haider, R Esteller, CD Hahn, MB Westover, JJ Halford, JW Lee, …
Neurology 87 (9), 935-944
97 2016
A comparison of fractal dimension algorithms using synthetic and experimental data

R Esteller, G Vachtsevanos, J Echauz, B Lilt
1999 IEEE International Symposium on Circuits and Systems (ISCAS) 3, 199-202
95 1999
Fractal dimension characterizes seizure onset in epileptic patients

R Esteller, G Vachtsevanos, J Echauz, T Henry, P Pennell, C Epstein, …
1999 IEEE international conference on acoustics, speech, and signal …
87 1999
Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control

JR Echauz, B Litt, R Esteller, GJ Vachtsevanos
US Patent 8,065,011
82 2011
High starting torque for AC SCR controller

A Ginart, R Esteller, A Maduro, R Pinero, R Moncada
IEEE Transactions on Energy Conversion 14 (3), 553-559
81 1999
Detection of seizure onset in epileptic patients from intracranial EEG signals

R Esteller
Georgia Institute of Technology
51 2000
Comparison of line length feature before and after brain electrical stimulation in epileptic patients

R Esteller, J Echauz, T Tcheng
The 26th Annual International Conference of the IEEE Engineering in Medicine …