Dr. Yun Guan is an associate professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. His multidisciplinary research focuses on mechanisms of chronic pain and developing better strategies and novel targets for treatment of pathological pain conditions.
Dr. Guan earned his M.D. from Capital Medical University in Beijing, China. Following that, he completed an M.S. in neurophysiology at Chinese Academy of Medical Sciences & Peking Union Medical College and a Ph.D. in neuroscience from the University of Maryland. He completed a postdoctoral fellowship in anesthesiology and critical care medicine at Johns Hopkins. Dr. Guan joined the Johns Hopkins faculty in 2006.
He is a member of the Society for Neuroscience, the American Pain Society (APS), the International Association for the Study of Pain and the North American Neuromodulation Society.
Dr. Guan serves on the editorial board of Analgesia & Resuscitation: Current Research. His work has been recognized with numerous awards, most recently Gold Medal award of the 13th, 14th and 15th ACCM Research Day at Johns Hopkins University.
The long-term goal of Dr. Guan’s research is to elucidate fully the peripheral (primary sensory neuron), spinal (secondary sensory neuron), and supraspinal (descending pain modulation) mechanisms of chronic pain and develop better strategies and novel targets for treatment of pathological pain conditions. His research is multidisciplinary in nature and encompasses electrophysiological, molecular biological, immunocytochemical, and behavioral pharmacological approaches to study neurobiological mechanisms of pain and hyperalgesia after tissue or nerve injury.
- Guan Y, Wacnik WP, Yang F, Carteret AF, Chung CY, Meyer RA, Raja SN. Spinal cord stimulation-induced analgesia: Electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats. Anesthesiology113(6):1392-405, 2010. Accompanied by an Editorial View.
- Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ*, Dong X*. The inhibitory effect of Mas-related G-protein-coupled receptors on pathological pain in mice. Proc Natl Acad Sci U S A107(36):15933-15938, 2010.
- Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH Unmyelinated low threshold mechanoreceptors are required for injury-induced mechanical hypersensitivity. Nature 462(7273):651-655, 2009.
- Guan Y, Johanek LM, Hartke TV, Shim B, Tao YX, Ringkamp M, Meyer RA, Raja SN. Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain 138(2):319-329, 2008.
- Guan Y, Borzan J, Meyer RA, Raja SN. Windup in dorsal horn neurons is modulated by endogenous spinal µ-opioid mechanisms. J Neurosci 26:4298-4307, 2006.